Metallo β-lactamase ligand 1( —— )

Catalog No. M28184 CAS No. 1087784-71-1

Metallo β-lactamase ligand 1 is an inhibitor of class B β-lactamase exhibiting antibacterial activities.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Metallo β-lactamase ligand 1
Note

Research use only, not for human use.
Brief Description

Metallo β-lactamase ligand 1 is an inhibitor of class B β-lactamase exhibiting antibacterial activities.
Description

Metallo β-lactamase ligand 1 is an inhibitor of class B β-lactamase exhibiting antibacterial activities.(In Vitro):The toxicity of Metallo β-lactamase ligand 1 is extremely low in HeLa cells.(In Vivo):Administration of Metallo β-lactamase ligand 1 significantly improves the survival rate in mice infected with an experimental strain (E. coli strain into which a plasmid encoding class B β-lactamase (IMP-1) is introduced).
In Vitro

One effective measure against β-lactam antibacterial resistant bacteria is to use an inhibitor of β-lactamase, the enzyme responsible for its resistance mechanism, together with an appropriate β-lactam antibacterial agent. The toxicity of Metallo-beta-lactamase ligand 1 (Compound A) is extremely low in HeLa cells.
In Vivo

After infecting mice with an experimental strain (E. coli strain into which a plasmid encoding class B β-lactamase (IMP-1) is introduced), Metallo-beta-lactamase ligand 1 (compound A; 100 mg/kg; intraperitoneal injection) is administered, and life and death are observed. Administration of Metallo-beta-lactamase ligand 1 (compound A) significantly improves the survival rate.
Synonyms

——
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

IL-1β| IL-10
Research Area

——
Indication

——

Chemical Information

CAS Number

1087784-71-1
Formula Weight

219.21
Molecular Formula

C7H9NO5S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 250 mg/mL (1140.41 mM)
SMILES

Cc1oc(C)c(c1C(O)=O)S(N)(=O)=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Badria FA, Ameen M, Akl MR. Evaluation of cytotoxic compounds from calligonum comosum L. growing in Egypt. Z Naturforsch C J Biosci. 2007 Sep-Oct;62(9-10):656-60.

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